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3): (1) comprehensive elucidation of molecular mechanisms underlying the antitumor effects, specifically utilizing advanced methodologies including single-cell sequencing and multi-omics approaches [18, 88, 89, 91, 92, 126]

This mechanism is driven by IR-induced Nuclear Receptor Coactivator 4 (NCOA4)-mediated ferritinophagy regulation and has been demonstrated in both intestinal and vascular endothelial tissue, contributing to a cascade of free radical and lipid peroxide formation [44,45,46]

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Diseases like cancer, AIDS, type 2 diabetes, hepatitis and Parkinsons can also cause levels of this antioxidant to fall