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These include the clearance of potentially detrimental metabolites and protein fragments, such as soluble A, from the brain [14], influencing tau protein dynamics [8], supporting the function of the blood-brain barrier (BBB) [15], maintaining synaptic integrity [16], consolidating memory [17], modulating glial activation [18], and regulating neuroinflammation [19]
The outcome can be approval, a Complete Response Letter (requesting more information), or rejection
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