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Summary: GLP-1 receptor agonists are not licensed or recommended for treating addiction in the UK, though emerging research suggests they may influence reward pathways and substance use behaviours
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GLP-1 directly regulates insulin secretion, while GLP-1 RAs have the potential to improve insulin sensitivity and glucose homeostasis by attenuating inflammatory pathways such as NF-B and the NLRP3 inflammasome signaling, thereby mitigating IR [40]
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