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In the Billon 2023 paper, a single 25 mg/kg intraperitoneal dose in mice was enough to induce an acute aerobic exercise transcriptional signature in muscle within hours

Conclusion Carnitine as a dietary supplement has been touted as therapeutic for a variety of illnesses involving human carnitine deficiency and impaired fatty acid oxidation, implying that nutritional or pharmacologic carnitine supplements may be advantageous in some conditions

Overdosage of up to 4mg per week has been reported in clinical trials, with patients experiencing nausea