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DSIP administration did not significantly affect corticotropin-releasing-hormone (CRH)-stimulated or meal-induced ACTH and cortisol secretion, indicating thatcontrary to stress-protective effects reported in some animal studiesDSIP does not measurably blunt the human cortisol response
Strongest Current Evidence CagriSema REDEFINE 1 and REDEFINE 2 are completed phase 3 trials published in NEJM with over 4,600 participants
However, one study published in December 2020 did study the long term safety of Semaglutide in patients with T2DM, and it concluded that when taken on a long-term basis, Semaglutide was well tolerated and blood glucose levels were managed and maintained
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