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The synthetic alpha-MSH analog targets and activates melanocortin receptor 4, a potent mediator of sexual function in both men and women
For instance, in the DURATION-8 trial [36], once-weekly exenatide in combination with once-daily dapagliflozin did not lead to major hypoglycemia episodes over 104 weeks of treatment, with few events of minor hypoglycemia (1.7%)
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