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doi: 10.1093/eurheartj/ehad192 21 DaviesMJArodaVRCollinsBSGabbayRAGreenJMaruthurNMet al
Phase 2 Trials: Obesity A landmark phase 2 trial, published in The New England Journal of Medicine on June 26, 2023, evaluated retatrutides efficacy and safety in 338 adults with obesity (BMI 30 kg/m or 2730 kg/m with weight-related conditions, excluding T2D)
Example: 200 lb person = 240-300g protein daily Carbohydrates: Strategic timing IGF-1's glucose-lowering effects require careful carb management: Pre-workout: 40-60g carbs (fuel training) Post-injection: 30-50g fast carbs (prevent hypoglycemia) Post-workout meal: 60-80g carbs + protein (maximize nutrient uptake) Throughout day: 200-300g total depending on body size Fats: Don't neglect Supports hormone production 0.4-0.5g per lb body weight Focus on omega-3s (fish oil, salmon, walnuts) Hydration: Critical IGF-1 increases metabolic demands and protein synthesis, both water-intensive processes
Peripheral blood smear to look for abnormal cells or platelet clumping
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