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3 Newer medication classes, such as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose co-transporter 2 (SGLT-2) inhibitors, target some of the more recently identified defects described in the ominous octet. Agents from these medication classes are increasingly recommended in clinical practice guidelines and recommendations
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Changes in intracellular free Ca 2+ concentration were followed by fluorimetric analysis of fura-2loaded cells
