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The 10 structural models with the lowest associated energy from 100 calculated structural models were used to prepare figures using the PyMOL Molecular Graphics System, Version 2.4 (Schrdinger, LLC)
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The dose may be further escalated to 1 mg weekly and, if additional glycemic control is needed, to a maximum maintenance dose of 2 mg weekly
The clinical evidence base for this mechanism is robust: a peer-reviewed study in PLOS ONE confirming significant reductions in visceral adipose tissue with tesamorelin treatment compared to placebo across multiple patient populations supports the clinical rationale for using this peptide specifically for abdominal fat reduction
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