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Finan B, Ma T, Ottaway N et al (2013) Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans
While effective for some, these older medications sometimes came with significant side effects or limited long-term efficacy
[15] [16] For patients with established cardiovascular disease, chronic kidney disease, or high cardiovascular risk, NICE guidance now prioritises SGLT2 inhibitors as the preferred second-line agents after metformin, rather than either GLP-1 receptor agonists or DPP-4 inhibitors
An oral coformulation has been developed using the absorption enhancer SNAC to facilitate transcellular uptake across the gastric epithelium under research conditions [1,4,5]
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