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However, the landmark SURMOUNT-5 trial (published in mid-2025), which compared the two medications head-to-head, clarified the clinical reality: Total Weight Loss: Tirzepatide drives significantly greater total weight loss (averaging over 20%) compared to semaglutide (averaging roughly 14%)
This sublingual method allows the peptide to absorb directly through the mucosa of the mouth, bypassing the harsh environment of the stomach and potentially entering the bloodstream more efficiently
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Suspected adverse reactions to any medication should be reported via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk)
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