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Outcome measures include neurological severity scoring, rotarod and beam walk performance, histological assessment of lesion volume, and immunohistochemistry for axonal markers and myelin basic protein

A study of TP53 wild-type hepatocellular carcinoma has shown that, compared with monotherapy, the combination of the mTORC1 inhibitor everolimus with anti-PD-L1 antibodies significantly increases CD8 + T-cell infiltration and enhances tumor suppression [384]