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To verify the role of FTO in the process of cellular disulfidptosis, researchers treated UM cells with the FTO inhibitor meclofenamic acid (MA) and found that the m 6 A level within cells was significantly restored, the expression level of SLC7A11 was markedly upregulated, and a series of typical disulfidptosis features, such as cell shrinkage and disruption of the actin cytoskeleton, appeared in the cells, strongly confirming that inhibiting FTO can induce tumor cells to undergo disulfidptosis [112]
Nehme, M
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