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-MSH is a neuropeptide belonging to melanocortin family, and plays important role in stimulating melanogenesis as well as production of eumelanin, the pigment for skin and hair color
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In patients with heart failure, it is also possible that SGLT2-inhibitor-mediated improvements in cardiac function could translate into improved exercise capacity (a recent meta-analysis suggests a modest 20 m improvement in 6-min walk distance with SGLT2 inhibitors in patients with heart failure [162], and hence into increased physical activity with consequent benefit on deconditiong
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