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Reduced tolerance is the norm, not the exception
The score (the ancestor of the current MELD score), derived from a survival function, was calculated as follows: R=0.957 Loge(creatinine [mg/dl])+0.378 Loge(bilirubin [mg/dl])+1.120 loge (Prothrombin Time-International Normalized Ratio)+0.643 (cause of cirrhosis)
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It was submitted for regulatory approval in 2025, and results from the OASIS 4 clinical trials showed weight loss of around 13.6%, which is comparable to the injectable version
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