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In standard titration, GLP-1 medications such as semaglutide or tirzepatide are initiated at very low doses and gradually increased to help the body adapt and minimize potential side effects
A clinician who knows your history can help weigh potential benefits against risks and suggest monitoring plans
While some users described only mild side effects, such as constipation or nausea that became manageable after changing their diet, others talked about weeks or even months of severe diarrhea, bloating, chest pain, heartburn, and feeling full after only a few bites
These effects are generally mild to moderate in severity and tend to diminish over time as the body adapts to the medication
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