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This glucose-dependent mechanism ensures that insulin is secreted only when necessary, reducing the risk of hypoglycemia once blood sugar returns to normal

Detection of residual host cells after sex-mismatched bone marrow transplantation (BMT) using fluorescence in situ hybridization

Beyond long-standing dietary and vitamin-based management, recent developments include enzyme replacement therapy programs, pharmacological chaperone approaches designed to stabilize the CBS enzyme, and early-stage gene therapy candidates with one prior program (pegtarviliase) discontinued and succeeded by a newer candidate (rebranded SYNT-202) still progressing through development

Meron MK et al