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Importantly, as the chief brain source of APOE, astrocytes, especially those expressing the APOE4 allele, promote A aggregation, tau pathologies, BBB breakdown, and cerebrovascular dysfunctions (Wang M
High levels of visceral fat are strongly linked to insulin resistance, inflammation, and an increased risk of chronic conditions like Type 2 diabetes, heart disease, and metabolic syndrome
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Genetic factors influence individual responses, with 13-15% of patients seeing minimal results
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