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The classic clinical manifestations of plaque psoriasis are well-demarcated, erythematous, scaly plaques covered with silvery scales (202, 203)
10.1007/s11033-021-06676-4 102 MargulisB.TsimokhaA.ZubovaS.GuzhovaI
Malnick et al
Probing position N108, we found that incorporation of any other amino acid resulted in a substantially reduced formation of cyanidin ( 8 ) suggesting that the hydrogen-bond interaction of the asparagine to the flavonoid substrate is critical for dehydratase activity, while GSH-transferase activity was comparatively less affected for N108 variants comprising an alanine, histidine, tyrosine or tryptophan (Fig
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