DSIP is found in both free and protein-bound forms in the hypothalamus, limbic system, and pituitary gland, as well as in peripheral organs including the gut secretory cells, pancreas (where it co-localises with glucagon), and plasma with brain and plasma DSIP concentrations showing a marked diurnal variation that correlates with circadian rhythm in humans, with levels lowest in the morning and higher in the afternoon
3) Glycaemic and cardiometabolic endpoints in defined populations Some cagrilintide combination studies include participants with type 2 diabetes and report glycaemic endpoints such as HbA1c alongside weight change
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All investigations are performed in laboratory settings only
