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the difference between AOD-9604 arms and placebo was not statistically significant at either point, and development was terminated
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Hydroxocobalamin lasts longer, possibly needing less frequent doses
Some researchers eventually use up to 100mg daily for enhanced effects, though this should be approached gradually
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A 2021 review examining NNMT as a drug target explicitly notes that NNMT-inhibitor drugs remain limited in clinical use and that the field is still working out selectivity and delivery
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