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Low protein and calorie intake, electrolyte shifts like low sodium, and deficiencies in B12 or iron (low ferritin) can all cause: Fatigue Brain fog Depressed mood Before labeling Tirzepatide as the cause, I check: Daily protein intake, aiming for roughly 60 to 80 grams for many adults, depending on size and activity Hydration and salt intake should be considered if nausea or vomiting are present Labs: sodium, B12, ferritin, thyroid function, and glucose Who Might Be More At Risk For Mood Change On Tirzepatide
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Dosing every three days further smooths the curve, creating even more consistent plasma levels with smaller peaks and shallower troughs
Frequency: Weekly
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