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(NEJM, 2023) showed approximately 24% mean weight reduction with Retatrutide at 12 mg at 48 weeks, while Semaglutide demonstrated approximately 15% at 2.4 mg weekly in the STEP trials again, these are cross-trial figures drawn from studies with different designs and populations, and should be treated as indirect
Bouhlal S, Ellefsen KN, Sheskier MB, et al
Adverse events There was no statistically significant difference in the incidence of adverse events between treatment groups (Table 2)
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