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Both monothiol roGFP2 variants were rapidly glutathionylated with residue C208 reacting about twice as fast as residue C151 regardless whether PfGrx C32S/C88S (SSG) or PfGrx C88S (SSG) was used as the oxidant

In pediatric patients there was no statistically significant benefit, but in adult patients FEV1 values were significantly improved starting at three months, and the benefit persisted at the six- and nine-month evaluations

This GSH conjugation is spontaneous or enzymatic via GSH-S-transferases [21,22]