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One of the significant links between PCa, obesity, and metabolic disease may be due to insulin metabolism
For example, the hindbrain is responsible for integrating information necessary for energy homeostasis from diverse systems, including vagally mediated gastrointestinal signals, alterations in glucose and other circulating metabolites and descending neuroendocrine signals from the midbrain and forebrain 3
Once inside, it activates anorexigenic pathways
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