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It is known that ROS have detrimental effects, which are controlled by various cellular defense system, consisting of enzymatic (catalase, glutathione peroxidase and superoxide dismutase, etc.) compounds [2, 91]

Preclinical studies in lung and colorectal cancer show antitumor efficacy of MAT2A inhibitors, 41 , 42 and phase I clinical trials are ongoing in MTAP-deleted solid tumors and lymphomas ( clincaltrials gov

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