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Hematochezia causes Causes that affect the colon and rectum include: cancer hemorrhoids, which are swollen veins in the lower rectum diverticular disease, a condition where small pouches form and push outward through the colon wall arteriovenous malformations, which are a tangle of blood vessels connecting arteries and veins that disrupt blood flow ischemic colitis, which refers to inflammation in the colon due to reduced blood flow inflammatory bowel disease, which refers to long-term conditions that produce inflammation in the digestive tract Sometimes, hematochezia can come from the upper gastrointestinal tract

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When to Seek Medical Advice and Safety Precautions Immediate medical attention is required if any of the following occur during GLP-1 agonist treatment: Severe, persistent abdominal pain lasting more than a few hours Abdominal pain accompanied by repeated vomiting that prevents fluid intake Fever alongside severe abdominal pain Abdominal pain that progressively worsens rather than improves Yellowing of the skin or eyes (jaundice) Patients experiencing these symptoms should discontinue their GLP-1 agonist immediately and contact NHS 111, their GP urgently, or attend an emergency department depending on symptom severity

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