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The additional GIP receptor stimulation provides potentially synergistic benefits including enhanced insulin sensitivity in peripheral tissues, possible effects on adipose tissue metabolism supporting fat utilization, complementary satiety signaling through alternative neural pathways, and potential lean body mass preservation during weight loss periods
Monitoring thyroid function more closely during the first few months of Retatrutide treatment and adjusting levothyroxine doses as needed ensures continued adequate thyroid hormone levels
As a result, its not uncommon to experience feelings of weakness and extreme daytime sleepiness
The weight loss in the SELECT trial wasnt especially large on average, each participant lost around 8 to 9 percent of their body weight
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