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Versus retinol and retinoic acid (cosmetic anti-ageing reference): retinol acts via RAR/RXR receptors and transcriptional modulation but with irritating effects (desquamation, solar sensitivity)

Last reviewed: July 15, 2026 Last updated: July 15, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Community research plans often use 8 to 16 weeks, but those shorter structures are anecdotal and are not controlled clinical protocols