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Third, the study only included patients whose dose was escalated to 1.0 mg and lacked a control group of patients who maintained the 0.5-mg dose

Oral glutathione has very limited bioavailability and cannot reliably achieve therapeutic plasma concentrations

Transdermal delivery offers advantages for certain compounds, allowing steady release over 24 hours while bypassing first-pass liver metabolism

In PCOS specifically, where excess adiposity and hepatic steatosis are common amplifiers of an already-present insulin-resistant state, this route alone would be expected to lower hyperinsulinemia and, by extension, reduce the insulin drive to ovarian androgen synthesis