While the overall process is tightly regulated, it flexibly adapts to changing environmental conditions, enabling plasticity
For example, nitrogen balance was maintained in normal adult humans fed histidine-free diets for 8 days (Rose 1957), but there are no metabolic pathways for histidine synthesis in mammalian cells (Wu 2013)
When symptoms are attributed to high B12 intake, they typically include: Skin reactions : Acne-like eruptions or rosacea-type rashes, particularly with hydroxocobalamin injections (listed as rare adverse effects in the product information) Gastrointestinal disturbances : Mild nausea, diarrhoea, or abdominal discomfort Headaches : Occasional reports of headache following B12 injections Anxiety or restlessness : Anecdotal reports, though causation remains unestablished It is crucial to distinguish between symptoms caused by elevated B12 levels and those arising from the underlying conditions that elevate B12
Boyle EC, Brown NF, Finlay BB: Salmonella enterica serovar Typhimurium effectors SopB, SopE, SopE2 and SipA disrupt tight junction structure and function