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While not acutely dangerous, its not advisable without medical supervision
Cell 184 , 35023518.e33 (2021)
Acetoacetyl-CoA and an additional acetyl-CoA are converted to -hydroxy--methylglutaryl-CoA (HMG-CoA: 3-hydroxy-3-methylglutaryl-CoA) by mitochondrial HMG-CoA synthase (encoded by the HMGCS2 gene), an enzyme found in large amounts only in the liver and intestinal epithelial cells
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