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Collectively, these extra-hepatic effects create a favorable systemic metabolic environment that indirectly but substantially benefits hepatic steatosis and MASH
The fat-burning effect unfolds best in combination with moderate exercise and a protein-rich, low-sugar diet
Published trials including the SUSTAIN and STEP trial programs have demonstrated that semaglutide-based therapies may support meaningful weight reduction and improvements in metabolic markers in adults with overweight or obesity when used alongside dietary and lifestyle modifications
The ending date of 12/2022 was chosen to allow for a 12-month follow-up period by the time of data analysis on January 21, 2024
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