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Expect the first SubQ dose to feel less 'immediate' than IM because the depot release delays peak plasma concentration by 612 hours, but dermal tissue levels will be higher at 2448 hours than IM ever achieved
Laboratory investigations may include: NF-B signaling TNF- expression IL-1 and IL-6 pathway analysis COX-2 regulation Oxidative stress mechanisms Cellular inflammatory responses These studies focus on understanding molecular signaling rather than evaluating therapeutic outcomes
Caro JF, Poulos J, Ittoop O, Pories WJ, Flickinger EG, Sinha MK: Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver
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