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This study was published in the Endocrine Journal in 2021

In response to long term caloric restriction we adapt - we reduce heat production (thermogenesis) by changing our hormones and reducing the number of constantly active cell channels we express

Between patient populations with polyps and those with tumors, substantial variations in mucosal and fecal microbial configurations were found, with the most major changes being Enterobacteriaceae , which was elevated in the mucosa of patients with tumors compared to those with polyps, and Bacteroidetes , which was expanded in CRC tissues with tumor cells compared to those without tumors (Sobhani et al., 2011)

A typical Herxheimer reaction is temporary and followed by gradual improvement