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Nearly 45% of participants on the drug achieved weight reduction of 30% or more, a threshold Lilly described in a statement as an incredible number. The company also noted that a lower dose included in the study was associated with fewer discontinuations due to gastrointestinal side effects such as nausea and diarrhea
Upregulation of the brainstem preproglucagon system in the obese Zucker rat
GI effects are most pronounced
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