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We next generated a Glp1r Flp allele for use in combination with Lepr Cre ( Lepr Cre ;Glp1r Flp mice), thereby permitting the use of molecular genetic systems that require both Cre and Flp recombinases to manipulate Lepr Glp1r neurons without impacting other anatomically interspersed classes of Lepr neurons

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Whether that translates to a better overall outcome at the level of cardiovascular events, kidney protection, or long-term function is not yet known