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People with healthier, more diverse gut microbiomes tended to have better outcomes from acute infection
The glutamate residue is linked through its side-chain carboxyl, giving a gamma-glutamyl bond rather than a standard alpha-peptide bond, which is why the molecule resists most intracellular peptidases and is cleaved chiefly by gamma-glutamyl transpeptidase at the cell surface
It was found that the expression of GCH1 triggers the production of potent antioxidants BH4/BH2, which can block lipid peroxidation and ferroptosis, whether supplemented exogenously or produced endogenously
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