In contrast, antagonists of 2 adrenergic, dopamine D2, dopamine D3, and serotonin 5-HT2A/C receptors fail to affect tesofensine's hypophagic properties, indicating the specific receptor pathways responsible for its therapeutic effects
NICE guidance on obesity management (CG189) emphasises evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, andwhere appropriatepharmacotherapy with licensed medications such as orlistat or semaglutide (NICE TA875)
The fact is, however, although B12 injections may help, they wont solve all of your problems
Plus, alternatives for treatment if your protocol was impacted