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So a large oral dose still puts far less into circulation than a smaller injection
These data showed that subchronic (7 to 14 days) exendin-4 or liraglutide administration in rodents resulted in hyperactivation of the HPA, disruption of glucocorticoid circadian secretion, hypertrophy of the adrenal gland, and dysregulation of pituitary-adrenal stress responses [77]
Hu JX, Zhao CF, Chen WB, et al
These effects may be due to several plant compounds, such as quercetin, kaempferol, glucomoringin, chlorogenic acid, and isothiocyanate
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