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Mechanism studied NNMT catalyses the methylation of nicotinamide

What is supported in animal models Increased lipolysis, increased fat oxidation, decreased lipogenesis, no apparent effect on plasma glucose or insulin sensitivity, and signal that intact beta-3 adrenergic receptor activity matters for the fat-loss effect

The compounds research profile now spans adipose tissue biology, skeletal muscle physiology, gut microbiome modulation, cardiovascular metabolic pathways, and cancer cell biology

Kraus et al., Nature Medicine show that NNMT inhibition can increase energy expenditure and improve metabolic health without altering diet or activity