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22 In the PIONEER-6 trial evaluating oral semaglutide, among patients with T2DM, the CV risk profile was not inferior to that of patients in the placebo group but it did not show superiority of this agent to placebo
Rybelsus European Medicines Agency medicine page
The more cautious interpretation is that patients who receive GLP-1 receptor agonists may differ in important but incompletely measured ways from those treated with insulin or metformin, including overall health, treatment access, healthcare follow-up, or cardiometabolic care intensity
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