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Semaglutide is a GLP-1 receptor agonist alone, while tirzepatide activates both GLP-1 and GIP receptorsa dual mechanism that may enhance satiety and metabolic effects
As an indicative example, without its own effect on normal blood pressure, it counteracts L-NAME hypertension as well as L-arginine hypotension (Sikiric et al., 1997a)
From a practical syringe standpoint, someone using compounded semaglutide at 5 mg/mL who draws 10 units gets 0.5 mg of semaglutide
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