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The NAD(+) Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal [PMID: 38385069] Laboratory literature summary: The NAD(+) Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers'

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This enzyme is often overexpressed in adipose tissue in conditions of obesity and metabolic dysfunction, leading to the depletion of nicotinamide and reduced availability of NAD+