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Patients (n = 9,340) were randomised to liraglutide or placebo for 3.5 and up to five years and showed durable effects on glycated haemoglobin and on body weight
GLP-1 receptor agonists like semaglutide have transformed weight loss treatment, with clinical trials showing average weight reductions of 15-22% over 68 weeks
One proof-of-concept clinical trial in patients with obesity and type 2 diabetes
The pooled estimates derived from the included reviews are depicted in Figure 2 and Supplementary Figure S4
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