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Adherence is generally affected by a combination of capability (strength, dexterity, cognitive powers), opportunity (complexity, cost, availability) and motivation (intrinsic drivers, rewards, general mood).11 Based on this, it is possible to calculate relative differences in likely adherence with a quantitative analysis of typical disease impact, patient demographics, drug effects and device operating principles.12 By systematically analysing a drug delivery solution, it is possible to identify opportunities for improvement and determine the cost-benefit of investing in a wide range of design features
Enteric coatings could protect peptides from gastric acid but did not address enzymatic degradation or poor absorption in the small intestine
The translational imperative for multimodal strategies becomes particularly evident in complex clinical contexts such as traumatic brain injury, where the cascade of secondary insults, excitotoxicity, inflammation, oxidative stress, and delayed neurodegeneration demands comprehensive and patient-specific interventions
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