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Additionally, PPAR- influences the activity of mitochondrial uncoupling proteins (UCP) and acyl-CoA oxidase 1 (ACOX), both of which regulate ROS production
1 Introduction Methotrexate (MTX), a folate antagonist, is a competitive inhibitor of dihydrofolate reductase which converts dihydrofolate into tetrahydrofolate required for nucleic acid synthesis (Kremer, 2004
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