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In particular, one of oridonin derivate (HAO472) is currently in phase I clinical trials in China for the treatment of a type of leukemia ( 2+ concentrations, and hemolysis ( Benzethonium chloride is a synthetic quaternary ammonium salt with antimicrobial properties, widely used in liquid antiseptics, in cosmetics (National Center for Biotechnology Information), and as a preservative in vaccines (Yip et al., 2006)

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