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Consider other treatment options if progress is limited If someone has achieved the expected effect of semaglutide, a clinician may discuss other medicines that act on other appetite pathways
Extended Data Figure 9 The R176Q mutation decreases the potency of GLP-1R, but does not affect its binding capacity with GLP-1
Bloating: Slower stomach emptying and gut motility can lead to a build up of gas causing a feeling of fullness and abdominal distention
Patients with a family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 should not take semaglutide, as it could increase their risk for these diseases
