IGF-1 LR3 (Long R3 Insulin-Like Growth Factor 1) is a synthetic, lengthened analogue of human IGF-1 , designed to exhibit greater metabolic stability and reduced binding to IGF-binding proteins (IGFBPs)
A 2026 UK review of the A1/A2A mechanism, tolerance, the 56h half-life sleep tax, the record 2026 dementia data (~35% lower risk at 23 cups), energy drinks and the under-16s ban , the EFSA 400 mg / NHS 200 mg limits, the BDNF link and the HGF/c-Met case and why caffeine hygiene, not a peptide, comes first Read the full review Psychopharmacology & Cognitive Neuroscience 22 June 2026 Dihexa for SSRI & Antidepressant Brain Fog: Emotional Blunting, Memory & the 2026 UK Review My mood is better on my antidepressant so why do I feel foggy, flat and half-switched-off? A record 8.89 million people in England were prescribed antidepressants in 2024/25 ( NHSBSA : 92.6 million items), and an estimated 4060% of SSRI users report emotional blunting
GLP-1 works in the following ways: It stimulates the pancreas to release insulin (which lowers blood glucose), suppresses the release of glucagon (a hormone that raises blood glucose)
And outside of a few specific uses (like GLP-1 medications), theres still limited high-quality human research on many of the peptides being promoted online